IMMUNITY 17/1 (2002) 31-40

Initiation of NALT organogenesis is independent of the IL-7R, LTβR, and NIK signaling pathways but requires the Id2 gene and CD3^-CD4⁺CD45⁺ cells

Fukuyama S., Hiroi T., Yokota Y., Rennert P.D., Yanagita M., Kinoshita N. , Terawaki S., Shikina T., Yamamoto M., Kurono Y., Kiyono H.

Department of Mucosal Immunology, Res. Inst. for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan

Abstract
Initiation of nasopharyngeal-associated lymphoid tissue (NALT) development is independent of the programmed cytokine cascade necessary for the formation of Peyer's patches (PP) and peripheral lymph nodes (PLN), a cytokine cascade which consists of IL-7R, LTα1β2/LTβR, and NIK. However, the subsequent organization of NALT seems to be controlled by these cytokine signaling cascades since the maturation of NALT structure is generally incomplete in those cytokine cascade-deficient mice. NALT as well as PP and PLN are completely absent in Id2^-/- mice. NALT organogenesis is initiated following the adoptive transfer of CD3^-CD4⁺CD45⁺ cells into Id2^-/- mice, constituting direct evidence that CD3^-CD4⁺CD45⁺ inducer cells can provide an IL-7R-, LTα1β2/LTβR-, and NIK-independent tissue organogenesis pathway for secondary lymphoid tissue development.

Initiation of NALT organogenesis is independent of the IL-7R, LTβR, and NIK signaling pathways but requires the Id2 gene and CD3-CD4+CD45+ cells

Fukuyama S., Hiroi T., Yokota Y., Rennert P.D., Yanagita M., Kinoshita N. , Terawaki S., Shikina T., Yamamoto M., Kurono Y., Kiyono H.

Department of Mucosal Immunology, Res. Inst. for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan

Initiation of NALT organogenesis is independent of the IL-7R, LTβR, and NIK signaling pathways but requires the Id2 gene and CD3^-CD4⁺CD45⁺ cells