IMMUNOL. CELL BIOL. 71/3 (1993) 209-214

The maintenance of self-tolerance

Lafferty K.J., Gill R.G.

Barbara Davis Cnt. Childhood Diab., University of Colorado, Health Sciences Center, 4200 E. 9th Avenue, Denver, CO 80262, USA

Abstract
Two signal models for lymphocyte activation build on the Talmage/Burnet concept that receptor diversity is generated within the immune system by a random process, and that individual lymphocytes carry a single receptor on their surface that determines their specificity. Such models cannot use a concept of signal one anergy (or deletion) to explain the maintenance of self-tolerance in terms of the Bretscher/Cohn theory if they abandon the concept of associative recognition.

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