LANCET 355/9216 (2000) 1693-1694

Retrospective study of prion-protein accumulation in tonsil and appendix tissues

Ironside J.W., Hilton D.A., Ghani A., Johnston N.J., Conyers L., McCardle L.M. , Best D.

National CJD Surveillance Unit, Western General Hospital, Edinburgh EH4 2XU, UK

Abstract
To identify individuals who could be at high risk of developing vCJD, a sensitive immunohistochemical technique was used to detect prion protein in a retrospective series of over 3000 tonsil and appendix specimens. No positives were detected but further studies are required to help reduce uncertainties about possible future numbers of vCJD cases in the UK.

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