VOX SANG. 76/4 (1999) 203-208


The relationship between new variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy

Knight R.

National CJD Surveillance Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK

Abstract
Creutzfeldt-Jakob disease (CJD) has been transmitted in the laboratory and also by iatrogenic accident. However, research has failed to find evidence that its most common form (sporadic CJD) is a natural infection and, in particular, that there is a causal link with scrapie. Bovine spongiform encephalopathy (BSE) probably resulted from scrapie infection in cattle food. In the wake of the BSE epidemic, a novel clinico-pathological form of CJD has been recognized: new variant CJD (nvCJD). This paper reviews the relationship between nvCJD and BSE and presents the accumulated evidence supporting the view that nvCJD resulted from BSE contamination of human food.


 

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